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The CFX effects are the same as the DFX. An outboard Lexicon will sound better than the built in on the Mackie just because Lexicon makes a great processor. The MPX550 is a very nice processor - but honestly a little overkill when the MPX110 will sound just as nice. The 550 has some better reverb patches in it, but not enough your going to be able to notice - it is better suited for pro-live music & studios. The MPX110 isn't as programable is it's downside. But it does have a tap sync so you can tap to the beat & have a perfect effect every song.
Nice thing is with the CFX & an outboard effects, you can blend both the internal & external together for a more custom effect.
If you go for something like the Mackie 1642VLZ (my next board) series, you are going to have a cleaner sounding board than the CFX/DFX series - these use the same mic pre-amps that were found on their 8 buss recording boards & the 56 channel touring boards. Also more routing options especially if you want to record as well.
Thanks much Lonman. Mackie SR1530 and DBX 2215 EQ are my latest additions. They are unbelievable with my DFX-12. I'll upgrade my board and/or MPX110 when have the chance and $$$.... then move the DFX-12 to my "portable" system (Yamaha S112V, Crown CE1000 and BBE 362).